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| Anika Moa - Youthful |
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Anika Moa started her career when she was
just 13, when she began writing songs. She
writes all her songs and amongst other
instruments is more than handy on the guitar.
She was born in Auckland and raised in
Christchurch.
She is the first New Zealand artist to be
signed to a major US label without having
released an album. After hearing demos,
Warner NZ rang her up and said "let's go to
New York". When Atlantic Records heard her
they instantly signed her up. As a result she
is now signed to Warner New Zealand and
Atlantic Records in the USA.
Anika Moa is a singer/songwriter who needs
little introduction. She burst onto the New
Zealand music scene 3 years ago with the
double-platinum album 'Thinking Room'.
Singles such as 'Youthful', 'Good In My
Head', and 'Falling In Love Again' became
massive hits and led the charge in the
renaissance of local music on commercial
radio.
A plethora of touring followed in the wake of
this success. Aside from Anika's obvious
songwriting skills, her talents are nowhere
more apparent than when playing live. Anika
is a true raconteur — not just holding
audiences spellbound with her songs, but
keeping them entertained with her witty,
often hilarious, between song banter and
stories. She has the down-to-earth kiwi
humour that wins audiences over in an instant
and keeps them returning for more.
Anika is currently working on material for
her new album which she describes as being
"more raw and earthy" than it's predecessor.
Displaying her maturity as a songwriter,
Anika has opted to write about weightier
topics than the standard singer/songwriter
ruminations on love and life.
In her new works she explores the notion of
Aotearoa's nationhood, and in particular the
recurrent themes of her own Maori heritage
— the legacy of culture, land and tangata
whenua. Where was Maoridom then, where is it
now and where is it going? So few songwriters
dare to challenge themselves and audiences
anymore in the sanitised and 'play-it-safe'
culture of the modern global music industry.
In Anika Moa, New Zealand can lay claim to a
true artist using her voice intelligently and
thoughtfully.
She has collaborated with The Feelers lead
singer/songwriter James Reid on a number of
songs and they appear on her debut album.
Anika's debut single was 'Youthful' and her
debut album released in 2001 is called
'Thinking Room'.
Winner of Top Female Vocalist and Songwriter
of the Year in the 2002 NZ Music Awards!
http://www.muzic.net.nz/artists/192.html
http://www.anikamoa.com/
http://en.wikipedia.org/wiki/Anika_Moa
http://www.nzgirl.co.nz/articles/5244
Tags : NZ Kiwi New Zealand Music Anika Moa Youthful |
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Affichage : 13941
Durée : 264 s |
| MOA |
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Early Morning before going to MOA. kahit
nakablindfold nakaka-kilig pa rin .
Tags : holdinghands |
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Affichage : 15137
Durée : 331 s |
| CisPlatin: Mechanism of Action |
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Cisplatin is in a class of drugs known as
platinum-containing compounds used to treat
various types of cancers including metastatic
testicular and ovarian tumors. The molecule
was first discovered in 1845, but did not
receive FDA approval until 1978. Today it is
known as the "penicillin of cancer drugs,"
because it is so effective for many different
cancers. There are three key players involved
in Cisplatin's mechanism: (1) Cisplatin, (2)
DNA (3) and an HMG Protein. Most Cisplatin
enters the body through active transport, but
some molecules are passively defused through
the cell membrane.
Once in the nucleus, Cisplatin can form
an adduct with two consecutive guanine bases
within a strand of DNA. The molecule loses
its chlorine atoms in exchange for the
nitrogen atoms of the target guanines.
Cisplatin can bond more tightly with nitrogen
because nitrogen balances the platinum charge
more effectively than chlorine.
It is this adduct-induced DNA bend that
allows binding of proteins which contain the
high mobility group, HMG domain. Once the
protein is bound to the DNA, it inserts a
wedge-like phenyl group of phenylalanine 37
into the widened minor groove created by the
bend. The tightly bound HMG protein causes
destacking of the nucleotide bases, resulting
in the DNA helix becoming kinked. In this
way, Cisplatin can be thought of as a monkey
wrench in the DNA repair system. With the
HMG protein bound to the DNA, the modified
strand is not repaired properly and so the
cell dies. The success of Cisplatin depends
on its ratio of efficacy between cancerous
and healthy cells.
Created by
Nick O'Brien (STA Student);
Bongsup Cho
Tags : Cisplatin Cancer Drug URI Animation Mechanism Action |
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Affichage : 12174
Durée : 171 s |
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